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Liposome Calculator 螢幕截圖
About Liposome Calculator
Liposome Calculator helps in preparation of liposome solutions. Components concentrations (molarity and mg/ml) and moles, and volumes of stock solutions are calculated based upon data provided, such as: initial concentrations of the stock solutions, and required molar ratios.
Application is comprised of two activities: First is Calculator, that helps to parameterize and prepare the complex suspension systems. Second is Analyzer that helps in analysis of liposome parameters, such as number of molecules per vesicle, inner, entrapped volume and encapsulation.
The Calculator follows the common liposome preparation procedure (volard.wordpress.com):
1. Stock solutions of lipids (or any other compound) are mixed in appropriate molar ratios.
2.Obtained mixture is purged with nitrogen and organic solvent is finally evacuated under vacuum.
3.Obtained lipid mixture is hydrated and extruded or sonicated, according to the needs.
Calculator features:
Unlimited number of components is available. Additional components are added by touching “Solution# (+)” field and deleted by touching the “Molar% (-)” field.
Application is fully interactive: all system parameters are updated immediately after any input from user (if it is sufficient!). For example: final molar concentration and molar ratios of the components can be adjusted at any time if molar concentrations of starting solutions and final suspension volume are provided. Upon any of the aforementioned changes, the application will calculate the volumes of the initial solutions to fit the desired parameters.
The database is used to store compounds data, that will be available to autocomplete upon typing compounds' names in the main calculator.
Important points.
The user should follow the simple rule to ensure proper functionality: all known data should be provided in the following order (Only yellow fields are adjustable): solution or solute nicknames(optional)-> Mw (if needed)-> initial concentrations (must!)-> volumes (if known)-> molar ratios (if known)-> Total Molarity (if known)-> Total Volume (if known).
Sum of stock solution volumes doesn't have to be equal to final suspension volume (Refer to the procedure)!
Watch out the molar ratios to ensure that all starting components are included! Program will expel components for which insufficient data is provided! Thus, for example concentration in g/l cannot be included in calculations if Mw of solute is not provided.
Liposome Analysis Activity Layout:
The activity window divided to data panel (left) and results panel (right).
The data panel parameters:
Total Concentration: Total lipid concentration. Automatically uploaded from Liposome Calculator activity and can be corrected at any time.
Total Volume: Total solution volume. Automatically uploaded from Liposome Calculator activity and can be corrected at any time.
Diameter: Average liposome outer diameter in nanometers (one billionth of meter).
Bilayer Thickness: Lipid bilayer thickness in angstroms.
Molecular Area: Single lipid molecule area in square angstroms.
The results panel parameters:
Number of Molecules: Average number of lipid molecules in a single liposome (vesicle).
Number of Liposomes: Average total number of liposomes in the analyzed solution.
Inner Volume: Average volume entrapped in a single liposome.
Surface Area: Average surface area of a single liposome.
Encapsulation Efficiency: In this context is represented by ratio of the total entrapped volume to total solution volume. Look up for the definition in regards to the drug encapsulation.
Important Points.
Usage of high total concentrations (particularly in molar range) leads to an inappropriate system analysis (encapsulation efficiency values exceeding 100%), since physical state of system cannot anymore be considered as a dilute vesicle suspension.
Application is comprised of two activities: First is Calculator, that helps to parameterize and prepare the complex suspension systems. Second is Analyzer that helps in analysis of liposome parameters, such as number of molecules per vesicle, inner, entrapped volume and encapsulation.
The Calculator follows the common liposome preparation procedure (volard.wordpress.com):
1. Stock solutions of lipids (or any other compound) are mixed in appropriate molar ratios.
2.Obtained mixture is purged with nitrogen and organic solvent is finally evacuated under vacuum.
3.Obtained lipid mixture is hydrated and extruded or sonicated, according to the needs.
Calculator features:
Unlimited number of components is available. Additional components are added by touching “Solution# (+)” field and deleted by touching the “Molar% (-)” field.
Application is fully interactive: all system parameters are updated immediately after any input from user (if it is sufficient!). For example: final molar concentration and molar ratios of the components can be adjusted at any time if molar concentrations of starting solutions and final suspension volume are provided. Upon any of the aforementioned changes, the application will calculate the volumes of the initial solutions to fit the desired parameters.
The database is used to store compounds data, that will be available to autocomplete upon typing compounds' names in the main calculator.
Important points.
The user should follow the simple rule to ensure proper functionality: all known data should be provided in the following order (Only yellow fields are adjustable): solution or solute nicknames(optional)-> Mw (if needed)-> initial concentrations (must!)-> volumes (if known)-> molar ratios (if known)-> Total Molarity (if known)-> Total Volume (if known).
Sum of stock solution volumes doesn't have to be equal to final suspension volume (Refer to the procedure)!
Watch out the molar ratios to ensure that all starting components are included! Program will expel components for which insufficient data is provided! Thus, for example concentration in g/l cannot be included in calculations if Mw of solute is not provided.
Liposome Analysis Activity Layout:
The activity window divided to data panel (left) and results panel (right).
The data panel parameters:
Total Concentration: Total lipid concentration. Automatically uploaded from Liposome Calculator activity and can be corrected at any time.
Total Volume: Total solution volume. Automatically uploaded from Liposome Calculator activity and can be corrected at any time.
Diameter: Average liposome outer diameter in nanometers (one billionth of meter).
Bilayer Thickness: Lipid bilayer thickness in angstroms.
Molecular Area: Single lipid molecule area in square angstroms.
The results panel parameters:
Number of Molecules: Average number of lipid molecules in a single liposome (vesicle).
Number of Liposomes: Average total number of liposomes in the analyzed solution.
Inner Volume: Average volume entrapped in a single liposome.
Surface Area: Average surface area of a single liposome.
Encapsulation Efficiency: In this context is represented by ratio of the total entrapped volume to total solution volume. Look up for the definition in regards to the drug encapsulation.
Important Points.
Usage of high total concentrations (particularly in molar range) leads to an inappropriate system analysis (encapsulation efficiency values exceeding 100%), since physical state of system cannot anymore be considered as a dilute vesicle suspension.
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最新版本5.9更新日誌
Last updated on 2023年08月10日
歷史版本
Compatibility update.
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Version History
5.9
2023年08月10日
Compatibility update.
5.8
2022年05月16日
Compatibility update.
5.7
2022年01月20日
Compatibility update.
5.6
2021年07月18日
Compatibility update.
5.5
2021年04月17日
Compatibility update.
5.4
2021年01月06日
Compatibility update.
5.3
2020年11月22日
Compatibility update.
5.2
2020年08月06日
Compatibility update.
5.1
2020年03月27日
Compatibility update.
5.0
2020年02月25日
Compatibility update.
4.8
2019年01月31日
Compatibility update.
4.7
2018年08月15日
Compatibility update.
4.6
2018年02月16日
Compatibility update.
4.5
2018年02月03日
Compatibility update.
4.4
2018年02月01日
Compatibility update.
4.3
2018年01月29日
Compatibility update.
4.1
2018年01月20日
Compatibility update.
4.0
2018年01月15日
Compatibility update.
3.8
2018年01月11日
Compatibility update.
3.6
2018年01月04日
Compatibility update.
3.5
2017年12月17日
Compatibility update.
3.4
2017年12月08日
Compatibility update.
3.2
2017年11月25日
Compatibility update.
3.0
2017年11月13日
Compatibility update.
2.8
2017年11月10日
Compatibility update.
Liposome Calculator 價格
今日:
HK$ 32.00
最低價格:
HK$ 28.00
最高價格:
HK$ 32.00
Liposome Calculator FAQ
Liposome Calculator在以下限制國家以外的其他地區可用:
Latvia,Mongolia,Nigeria,Antigua And Barbuda,Bolivia,Belarus,Grenada,Georgia,Uganda,Uzbekistan,Azerbaijan,Lithuania,Malawi,Albania,Kenya,Cayman Islands,Serbia,Tajikistan,Senegal,Cote Divoire,Cameroon,Lebanon,Nepal,Bosnia & Herzegovina,Yemen,British Virgin Islands,Czech Republic,Jamaica,Turks and Caicos,St. Vincent & The Grenadines,Armenia,Ukraine,Kyrgyzstan,Guyana,Namibia,Papua New Guinea,Brazil,Ghana,St. Kitts and Nevis,Montserrat,Venezuela,Guatemala,Libya,Pakistan,Bermuda,Gabon,Honduras,Panama,Paraguay,Gambia,Hungary,Lao Peoples Democratic Republic,Madagascar,Mozambique,Barbados,Congo,Qatar,Slovakia,Zambia,Bulgaria,Bahrain,Dominica,Cambodia,Burkina Faso,Turkmenistan,Angola,Croatia,Solomon Islands,Micronesia,Kazakhstan,Moldova,Kosovo,Liberia,China,Costa Rica,Algeria,Jordan,St. Lucia,Palau,Sierra Leone,Malta,Poland,Seychelles,Congo, Democratic Republic,Morocco,Swaziland,Bahamas,Cape Verde,Mauritania,Trinidad and Tobago,Suriname,Uruguay,Fiji,Macedonia,Mali,Maldives,Bhutan,Tunisia,Tanzania,Vietnam,Vanuatu,Belize,Estonia,Egypt,Israel,Tonga,Russia,Colombia,Cyprus,Dominican Republic,Nicaragua,Anguilla,Benin,Botswana,Zimbabwe,Montenegro,Mauritius,Nauru,Oman,Chad,Guinea-bissau,Turkey,Argentina,Sri Lanka,Myanmar,Niger,Afghanistan,Romania,Ecuador,Iraq,Rwanda,Sao Tome & Principe,Macao,Slovenia,El Salvador
Liposome Calculator支持英文
點擊此處瞭解如何在受限國家或地區下載Liposome Calculator。
以下為Liposome Calculator的最低配置要求。
iPhone
須使用 iOS 15.2 或以上版本。
iPad
須使用 iPadOS 15.2 或以上版本。
iPod touch
須使用 iOS 15.2 或以上版本。